HPV53 positive will be infectious to men, HPV53 belongs to the low-risk human papillomavirus, through the oral mucosa, genital mucosa infection is transmitted through direct contact, if there is sex without using condoms and other safety measures, it is easy to infect each other, it is recommended that both sides at the same time examination and treatment. If there are warts can be laser treatment, at the same time can be reasonable use of antiviral drugs such as interferon, aciclovir, etc.. It is recommended to review HPV regularly to check the status of HPV53 treatment. If HPV positive persistently infected for more than one year long term, it may cause cervical cancer and TCT can be done. If cervical cancer is suspected, cervical biopsy is needed for pathological examination, and cervical cancer needs to be treated by surgery in time after it is determined.