In terms of treatment and management of HFMD, in fact, the main thing is to give symptomatic treatment, and mild cases are usually treated in outpatient clinics, while severe cases require inpatient treatment. Those with fever can be physically cooled or treated with antipyretic and analgesic drugs. In severe cases with neurological manifestations, mannitol can be considered to lower intracranial pressure, gammaglobulin and glucocorticoids as appropriate, and if cardiopulmonary function is not normal, mechanical ventilation and other comprehensive treatment may be required. There are no specific drugs to deal with the virus of hand, foot and mouth disease, and treatment should be combined with the actual situation.