Medulloblastoma grade 4 is usually treated by surgical removal of the medulloblastoma combined with radiotherapy and chemotherapy. Medulloblastoma is a highly malignant neuroepithelial tumor of the central nervous system. Currently, depending on the patient’s clinical stage and risk stage, surgery followed by radiotherapy and chemotherapy may be the treatment of choice. If radical surgery is not feasible, radiotherapy (e.g., vincristine-based drugs) can be used as early as possible to prolong the patient’s life. Although grade 4 medulloblastoma is highly malignant, as long as it is treated early, the patient’s life can be prolonged. Patients must try to do early detection, early treatment, timely control of the disease. At the same time, if you need to use drugs should be used under the guidance of a doctor, do not blindly use drugs.