Piperacillin and cephalosporin are both commonly used anti-infective drugs in the clinic, and it is impossible to distinguish which one is better, and different antibiotics are usually chosen through the patient’s specific infection. 1. Piperacillin: belongs to the penicillin class of antibiotics. By inhibiting the synthesis of bacterial cell walls, it has an antibacterial effect. It is mainly used for the treatment of sepsis, respiratory tract infections, urinary tract infections, biliary tract infections, abdominal infections, pelvic infections, as well as skin and soft tissue infections caused by sensitive Enterobacteriaceae, Pseudomonas aeruginosa, and Mycobacterium avium genus. 2. Cephalosporin: a general term for cephalosporin antibacterial drugs, belonging to the class of antibiotic drugs of the endocannabinoid class, with the efficacy of killing bacteria. Commonly, there are cefuroxime, ceftriaxone, ceftazidime cefoperazone, cefotaxime sodium and so on. Ceftazidime, for example, is mainly used for infections caused by sensitive strains of bacteria, such as Pseudomonas aeruginosa and other pseudomonas, Haemophilus influenzae, Klebsiella, Enterobacter, Proteus mirabilis, Escherichia coli, Pneumococcus, Staphylococcus aureus, etc. caused by respiratory tract infections, skin and soft tissue infections, urinary tract infections, bone and joint infections, gynecological infections, abdominal infections, and infections of the central nervous system, and other diseases. Piperacillin after the use of some patients can appear urticaria, leukopenia, nausea, vomiting, thrombophlebitis and other adverse reactions, penicillin allergic patients, pregnant women should be prohibited from use. Cephalosporins can appear diarrhea, stomach upset, nausea, lack of appetite, rash and other adverse reactions, patients allergic to cephalosporins, patients with renal insufficiency, pregnant women are prohibited. It is recommended that patients must standardize the use of drugs under the guidance of a professional doctor, do not take medication without authorization to avoid the occurrence of drug side effects, but aggravate the condition.