High uric acid and the endocrine system are generally related. The endocrine system realizes physiological functions through the secretion of hormones and mainly plays a role in regulating the metabolic process of the organism. It regulates the amount and composition of extracellular fluid, maintains the dynamic balance of the body’s internal environment, and regulates the body’s growth, development and reproductive functions. It can also enhance the body’s ability to resist or adapt to harmful stimuli and rapid changes in environmental conditions. And high uric acid may be caused by purine metabolism disorders, excessive urate production, and reduced renal excretion of uric acid. Therefore, high uric acid and endocrine system are generally related. It is recommended that patients with high uric acid should go to the hospital in time and follow the doctor’s instructions for treatment to avoid delay.