Thickening of the gallbladder wall is serious and may present with symptoms related to biliary diseases, neighboring organs, and primary diseases. 1. Biliary diseases themselves: colic or vague pain in the right upper abdomen or middle-upper abdomen, accompanied by poor appetite, lethargy, nausea, vomiting, diarrhea, and yellowing of the skin and sclera. 2. Thickening of the gallbladder wall caused by neighboring organs (e.g. cirrhosis of the liver) will result in loss of appetite, accompanied by nausea, vomiting, abdominal distension, jaundice and other symptoms. 3. Symptoms related to gallbladder wall thickening caused by systemic diseases are mainly symptoms of the primary disease, such as shortness of breath after activity and generalized swelling caused by heart failure; if gallbladder wall thickening is caused by renal failure, it will manifest as oliguria, anuria and other symptoms. If the above symptoms occur, it is recommended to consult a doctor in time and standardize the treatment.