A bone in the middle of the spine of the back will hurt when pressed may be caused by trauma, local structural changes, metastatic tumors of the spine and so on. 1. Trauma: If the back is bumped by external force, there will be local soft tissue injury or fracture, which will lead to pain when a bone in the middle of the spine is pressed. 2. Local structural changes: such as degenerative changes in the lumbar spine, lumbar disc herniation, etc., which may cause localized pain on pressure. 3. Metastatic tumor of spine: if the tumor occurs bone metastasis and involves the spine, it can destroy the local bone tissues and cause pressure pain and pathological fracture. A bone in the middle of the spine of the back will be painful when pressed, which may also be caused by other reasons. It is recommended to consult a doctor in time, take X-ray film and conduct magnetic resonance related examination to clarify the cause of the disease and then target treatment.