Cranial repair is a time-honored topic in medicine. Thousands of years ago, our ancestors began the medical practice of cranial bone repair, only that the technology was still relatively crude, and the repair material was relatively simple, perhaps with a piece of flannel wrapped around the bone window and finished. After thousands of years of development, especially the continuous progress and improvement of modern medicine, cranial bone repair is now a very mature surgical procedure. Under modern medical conditions, perfect preoperative preparation, strict aseptic operation, systematic postoperative care and so on, have reduced the risk of cranial bone repair surgery to a very low level. At present, the risk of cranial repair surgery is mainly from the repair material. Titanium mesh material, which is commonly used in clinical practice, may have certain risks. Such as the patient’s postoperative response to cold and heat sensitivity, local chronic pain, more subcutaneous fluid; repair surgery, affecting the patient to receive CT, MRI and other medical examinations. If the more advanced polyether ether ketone PEEK material can be applied, then the risk of skull repair surgery can be reduced to a lower level, or even almost no risk. Currently, our team uses the latest polyetheretherketone PEEK material for cranial bone repair surgery, which has been a great success and also well received by patients. This PEEK material is biocompatible, capable of complex molding, excellent mechanical properties, good protective properties, high postoperative comfort, and is gradually becoming the latest trend in cranial bone repair materials.