There are many adverse reactions brought by taking chemotherapy drugs, the common ones are myelosuppression, gastrointestinal reaction, cardiotoxicity, liver and kidney damage, hand-foot syndrome. 1. Myelosuppression: after 1-2 weeks of chemotherapy, some patients will experience myelosuppression, i.e., different degrees of decline in white blood cells, hemoglobin or platelets, which is also a reaction of most chemotherapeutic drugs. 2. Gastrointestinal reactions: the most common adverse reactions in the early stage of chemotherapy, manifested as nausea, loss of appetite, and in severe cases may cause vomiting, which is a relatively common type of reaction. In addition to gastrointestinal reactions, some patients may have diarrhea, constipation or fatigue, which may cause blood in the stool and intestinal mucosal necrosis and perforation in severe cases. 3. Cardiotoxicity: some chemotherapeutic drugs can produce cardiotoxicity, damage to cardiomyocytes, patients experience panic, chest tightness, pre-cardiac discomfort, shortness of breath and other symptoms, and even heart failure. T-wave changes or S-T segment changes may also appear on ECG examination. It is mostly seen with anthracycline chemotherapeutic drugs. 4. Liver and kidney damage: chemotherapy will have a certain effect on the patient’s liver, patients often have elevated aminotransferases, elevated bilirubin, causing jaundice, as well as fatigue, abdominal distension and pain, and vague pain in the liver area. With the increase in the number of chemotherapy treatments, the impact on renal function may become more and more significant, especially the more commonly used chemotherapeutic agent cisplatin. Patients may experience a transient or sustained decline in renal function. 5. Hand-foot syndrome: the typical manifestation of a progressive aggravation of skin lesions, the first symptom for the palms of the hands and soles of the feet skin itching, palms, fingertips and soles of the feet congestion; followed by finger/toe end pain sensation, skin erythema, sensory dullness, numbness, skin roughness, cracked, a small number of patients may be finger skin cut finger-like skin breakage, blisters, desquamation, oozing, and even ulceration and infection. Chemotherapy drugs that cause hand-foot syndrome include capecitabine and doxorubicin. In addition to the above common adverse reactions, due to the type of drugs and different physical condition of patients, other adverse reactions may also occur during chemotherapy. Patients are advised to use the drugs under the guidance of their doctors, and if discomfort occurs, they should seek timely medical treatment to avoid aggravation of the condition.