The probability of contracting hepatitis B between couples is low. On the one hand in the context of hepatitis B vaccination, the adult population has experienced immunization and is generally not infected when having sexual relations with people with hepatitis B. The small probability of infection occurs in people who were not vaccinated when they were young, or whose antibodies disappeared after vaccination, or who did not produce antibodies after vaccination. Therefore, pre-marital examination for hepatitis B and hepatitis B vaccination at the right time is an effective way to prevent hepatitis B transmission between couples. Patients with hepatitis B are mainly treated with medication and daily care, and they should pay attention to personal hygiene, develop good hygiene habits and pay attention to personal protection.