The human body has a biological rhythm for many functional activities, and blood pressure fluctuations also follow the pattern of biological rhythm changes. Blood pressure begins to rise in the early morning, reaches a maximum during the day, begins to fall at night, and drops to a minimum at midnight. In most people, blood pressure peaks between 6 and 8 in the morning and 8 in the evening, with the latter peak being higher than the previous one. Patients with hypertension should not simply take their medication according to the time of day, but should monitor their blood pressure for 24 hours to clarify their blood pressure fluctuation pattern and take their medication in time before the peak of blood pressure. For patients who take medium- or short-acting antihypertensive drugs, they should take an additional antihypertensive drug before the effect of the last one they took decreases or before another blood pressure peak comes. For example, a hypertensive patient who has a blood pressure peak at 6-8 in the morning and evening should take antihypertensive medication twice a day, once immediately after waking up in the morning, and then get up to wash, morning exercise, etc.; the second time should be taken at 4-5 in the afternoon to ensure good control of the second blood pressure peak and achieve the purpose of stable blood pressure reduction. In short, hypertensive patients should really realize the principle of anti-hypertensive treatment according to their own blood pressure fluctuation rules and insist on taking it.