Water-soluble statins are good and fat-soluble statins have their own advantages and disadvantages, and it is generally not possible to describe them in terms of which one is better. Statins mainly exert their effects in the liver and can effectively reduce cholesterol synthesis. Water-soluble statins such as Rosuvastatin are not easy to penetrate the cell membrane, and generally need to be transferred to the liver cells by the cell membrane surface transport protein, the efficacy of the drug is slower to play, so the water-soluble statin is more selective for the cells, and is not easy to act on other cells, and therefore have fewer side effects. Fat-soluble statin such as lovastatin can easily penetrate the cell membrane and can enter into the liver cells faster to play a role, but the selectivity of the liver cells is low, and it can also enter into other cells, and even penetrate the blood-brain barrier into the central system, causing headache, memory loss, dizziness and other side effects. Both have their own advantages and disadvantages, there is no one better, should be used under the guidance of a physician.