Thick calluses on the hands are medically referred to as calluses. Prevalent in the pressure and friction, manifested as yellow or wax yellow thickened keratinous plaques, the center thicker edge thin, solid texture, unclear boundary, smooth surface and clear lines. Treatment methods mainly include drug treatment, closed injection treatment, surgical treatment and usual care. 1. Medication: callus is caused by a large proliferation of the stratum corneum, treatment can be used to dissolve the stratum corneum of drugs such as high-concentration urea cream, salicylic acid ointment and so on. 2. Closed injection treatment: mainly refers to the use of corrosive drugs closed injection, so that the callus and the callus around the tissue completely stripped, usually can use anhydrous alcohol, isopropylazine injection subcutaneous injection treatment. 3. Surgical treatment: it refers to the gradual elimination of the stratum corneum with a sharp blade until the pink tender skin is exposed, which must be operated by a doctor in a professional organization. 4. usual care: callus itself has a certain protective effect, long-term labor or sports callus produced by the recommended treatment is not necessary. In normal life, pay attention to reduce hand friction, adhere to the use of moisturizing cream can reduce the formation of callus. After the formation of callus, do not trim by yourself, so as not to cause infection. It is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor to standardize the treatment, the use of drugs need to follow the doctor’s instructions.