Interferon is the first-line drug for the treatment of hepatitis B. It is an effective way to enable patients with hepatitis B to achieve clinical cure. Only patients with indications for interferon therapy should be treated with interferon as much as possible to achieve clinical cure. In addition, in addition to anti-virus, interferon also has anti-tumor, anti-proliferative, immune regulation effect, for hepatitis B virus-infected patients with interferon treatment has the effect of preventing the occurrence of hepatocellular carcinoma. In the process of using interferon, some flu-like symptoms can appear in the early stage, and most of them can be improved in the short term after active treatment. In the process of long-term treatment, we must pay attention to monitor whether there is any endocrine index abnormality such as thyroid gland.