Patients who stay up late for a long time will cause insufficient blood supply to the brain: first of all, those who stay up late for a long time will experience sympathetic hyperexcitation, and when sympathetic tone increases, it will lead to enhanced myocardial contraction, increased heart conduction velocity, and increased oxygen consumption of the heart, therefore, patients will have insufficient myocardial blood supply, and insufficient blood supply to the cerebral vessels will also occur in the case of long-term insufficient myocardial blood supply, which will lead to ischemia of the surrounding target organs and organs. It can trigger the occurrence of cerebral artery insufficiency of blood supply. In addition, when patients stay up late for a long time, they will have hyper-secretion and activation of the renin-angiotensin-aldosterone system, which will lead to an increase in blood pressure in the case of increased secretion of aldosterone, thus causing further impairment of cerebral blood supply and cerebral circulation. In addition, prolonged late-night sleep can also cause dysregulation of the neurohumoral-endocrine system, which can also cause cerebrovascular blood supply deficiency.