The pain that occurs when pressing on a gray nail is usually due to a local bacterial infection that causes inflammation and pain. Gray nails themselves usually do not produce painful symptoms. The main damage is to the cuticular part of the nail, which has no nerve endings distributed on the body, so no pain is felt. As the disease progresses, the thickened nail will compress the nail bed, which may lead to secondary infection of the soft tissues around the nail, causing complications such as onychomycosis and onychomycosis, in which case the pain will be felt when pressing. If a patient with gray nail has pain when pressing the affected nail, it is recommended to go to a regular hospital in time for diagnosis and treatment under the guidance of a doctor. The first step is to treat the local bacterial infection. In the early stage, physical therapy or hot compresses, topical fusidic acid cream or mupirocin ointment, oral amoxicillin capsules, or roxithromycin capsules can be used for anti-inflammatory and anti-infective treatment. If there is pus formation, incision and drainage treatment is required. After the inflammation is eliminated, treatment of gray nails is required. Oral treatment with terbinafine and itraconazole, and topical treatment with terbinafine ointment and sertaconazole ointment are available. If necessary, treatment such as diseased nail removal, laser, and photodynamic therapy is required.