Headache at ten o’clock every night is usually caused by poor sleep quality, insufficient cerebral blood supply, cervical spondylosis and cluster headache. 1. Poor sleep quality: if the patient usually mental stress is relatively large, often stay up late, in the sleep time will be prone to insomnia, often dreaming and so on, due to the brain does not get enough rest, it is easy to cause the symptoms of headache at ten o’clock every night. 2. Insufficient cerebral blood supply: patients suffering from hypertension, hyperlipidemia and atherosclerosis are likely to have insufficient cerebral blood supply, which slows down the body’s blood circulation at night, thus causing headache symptoms. 3. Cervical spondylosis: for some patients who have cervical spondylosis, if the bed is soft and the pillow is high, it is easy to compress the vertebral artery or nerve root, which will cause headache at ten o’clock every night. 4. Cluster headache: attack without aura, can be attacked at night, so that the patient woke up from sleep pain. The headache is located in one side of the eye socket and front temporal area, can be accompanied by the same side of the conjunctiva congestion and bleeding, eyelid edema or nasal congestion and runny nose, sometimes pupil narrowing, eyelid redness and other symptoms, most of the non-pulsating severe pain. There are many reasons that cause patients to have a headache at ten o’clock every night, patients should go to the hospital in time to do the relevant examination, to avoid delaying the condition and causing adverse consequences.