Pepsinogen is a digestive enzyme, which is a product secreted by the main cells of gastric fundus, mucus neck cells and mucus neck cells of cardia gland and pylorus gland of gastric sinus, and it has two fractions, which are divided into pepsinogen 1 and pepsinogen 2, called PG1 and PG2 respectively, and the pepsinogen ratio is PG1/PG2, which is the main factor to judge the pathology of stomach, and the normal value is ≥7.5. If the pepsinogen ratio If the pepsinogen ratio is between 3.0 and 7.5, it indicates that there may be H. pylori infection or gastric mucosal erosion or ulcer in the stomach; if the pepsinogen ratio is <3.0, it indicates poor secretion of gastric glands, which may be atrophy of gastric glands, seen in atrophic gastritis or gastric cancer. If the patient has a simple low pepsinogen with no other accompanying symptoms, no special medication is usually needed and regular review is sufficient. If the patient has poor digestive function or abnormal stomach discomfort in addition to low pepsinogen, he or she should go to the hospital in time to improve relevant examinations, such as gastroscopy and H. pylori testing, and then take reasonable treatment for the specific symptoms, such as lansoprazole, bismuth potassium citrate, digestive enzymes, probiotics and other drugs as prescribed by the doctor. In addition, it is necessary to do a good job in the diet, do not eat cold, stimulating food.