The causes of headaches from 2:00 to 3:00 in the middle of the night usually include neurological headaches, migraines and cluster headaches, etc., which need to be treated by a doctor as soon as they are detected. 1. Neurogenic headache: Neurogenic headache can often be manifested as head tension, swelling and pain, which can occur at night. Most of them are induced by mental tension and excessive pressure, and excessive fatigue can also induce neurological headache to aggravate the onset of attack. You should live a regular life, relax your mood, and take ibuprofen, diclofenac and other medicines according to the doctor’s instruction to treat the seriousness of the headache. 2. Migraine: Migraine can also be manifested as pain in the side of the head in the middle of the night, mental stress, overexertion is more common in female patients, headache attacks can take ibuprofen, sumatriptan and other drugs for relief, the use of medication needs to be carried out under the guidance of a professional doctor. 3. Cluster headache: the main manifestation of headache occurs suddenly, the time is relatively fixed, can occur at night, the site of one side of the periorbital, supraorbital, behind the eyes or temporal was sharp, explosion-like pain, the pain is more intense. It can be treated with oxygen and medication such as sumatriptan. If the above symptoms occur for a long time, it is recommended to go to the hospital in time to clarify the cause of the disease so as not to delay the condition.