The skull is an essential bone in the human body and an important insurance button for the human brain, because with the protection of the skull, the human brain tissue can work in an orderly manner. However, many people have serious damage to the skull due to some external factors in their lives. It is very serious when the brain tissue is exposed by skull defect, and what needs to be done at this time is to do skull repair surgery. On the one hand, the skull defect will seriously affect the patient’s appearance, some patients will have collapse phenomenon, some will have bulge phenomenon; on the other hand, the brain tissue because of the loss of the external protection of the skull, it is easy to suffer external damage, triggering similar problems such as abnormal cerebrospinal fluid circulation and blood supply disorders. In medicine, cranial repair surgery is a routine operation to repair the defective part of the skull, to achieve the integrity of the skull and to restore the confinement of the intracranial tissues. Generally speaking, the best time for cranial repair surgery is within 2-3 months after debridement surgery. Patients must seize the time and go to a regular hospital for skull repair surgery as early as possible. What is the best material for skull repair? During the whole skull repair surgery, the choice of material will directly affect the post-operative recovery effect. In the early days, the materials used for skull repair surgery were plexiglass, bone cement, etc. Later, titanium mesh material appeared, which may have some progress than the previous materials, but there are also some disadvantages, such as the possibility of postoperative infection and possible rejection. In view of all the disadvantages of these materials, medicine has now introduced a more advanced polymer material – peek material, which has achieved very significant results in clinical practice.