Girls taking melatonin for a long time may have certain side effects, such as drug dependence, endocrine disorders, etc., especially when taken for a long time without medical advice, the side effects may be more obvious. Melatonin is a hormone produced by the pineal gland of mammals, with sedative, hypnotic and analgesic effects, and does not require exogenous supplementation under normal circumstances. If there is a sleep disorder or need to adjust jet lag and other conditions, you can exogenously supplement melatonin. However, as a hormone, it is not recommended that girls take it for a long time. 1, drug dependence: girls taking melatonin for a long time will affect the normal secretion of melatonin by the pineal gland, disrupting the sleep rhythm, and may need to continue taking melatonin to sleep normally, which in the long run can lead to drug dependence; 2, endocrine disruption: long-term use of melatonin may inhibit the normal secretion of sex hormones in girls, inhibit the normal development of the gonads, and may even affect The quality of follicles, which may lead to infertility; 3, other symptoms: some girls due to poor metabolic capacity, long-term use of melatonin may appear headache, drowsiness, depression, memory loss, etc., affecting the normal study and work. Melatonin is usually widely marketed as a health product, and many girls will take it without permission after purchase, without consulting a relevant doctor, which can easily cause harm. In addition, after long-term use, when the harm is known and the sudden discontinuation of the drug, this will break the original sleep pattern, memory loss, nausea, anxiety, depression and other symptoms, will also cause discomfort to girls. It is recommended that girls with more serious symptoms seek medical attention to clarify whether other problems have arisen. Therefore, girls should avoid taking melatonin for a long time, if you need to take the right amount of supplementation should follow medical advice, so as not to cause serious consequences.