Large blackheads refer to open acne in medicine. Open acne can be handled by medication and chemical peeling. 1. Medication: patients can follow the doctor’s instructions to use topical retinoic acid drugs, such as Apadarine gel, retinoic acid cream, etc., which can play a role in regulating cell differentiation and dissolving acne. 2. Chemical peeling: patients can use chemical peeling to help assist in the treatment, is the use of fruit acids, salicylic acid and other effects on the local skin, can make the epidermis peeling, promote the dermal elastic fiber proliferation, to help improve the situation of blackheads. 3. Other treatments: you can use an acne squeezer under the guidance of a doctor to help remove blackheads There are more ways to deal with open acne, so patients are advised to go to the hospital and cooperate with doctors for standardized treatment.