Diffuse lesions of cardiac blood vessels are mostly atherosclerosis, usually related to high blood pressure, high blood lipids, high blood sugar, and need to be treated with medication according to the cause of the disease. 1. High blood pressure: When blood pressure increases continuously, it changes the blood flow dynamics and harms the endothelial cells of blood vessels, which will cause atherosclerosis. It is necessary to take angiotensin ll receptor antagonist, such as Irbesartan, Chlorosartan, etc. as prescribed by the doctor. Blood pressure should be regularly monitored and recorded during treatment. 2. Hyperlipidemia: After the blood lipid continues to increase, it may lead to the deposition of lipid plaques on the blood vessel wall, which is easy to cause atherosclerosis. Long-term oral statin drugs, such as atorvastatin, resuvastatin, simvastatin, etc., should be taken; physically obese patients should increase their activity level appropriately and control their weight. 3. High blood sugar: when the blood sugar level continues to rise, leading to lipid metabolism disorders, easy to cause atherosclerosis. Long-term oral hypoglycemic drugs, such as metformin, should be taken; when atherosclerosis occurs, then combined with vasodilator drugs, such as nitroglycerin, isosorbide nitrate. Diet as low as possible to low sugar, low fat, low calorie as the principle. Diffuse lesions found in the heart blood vessels, should go to the hospital as soon as possible to do cardiography to analyze the cause, and then combined with the doctor’s recommendations targeted treatment.