Chemotherapy may cause an increase in GGT. GGT, also known as glutamyl transpeptidase, is widely found in human organs and tissues such as kidney, pancreas, liver, brain, skeletal muscle and cardiac muscle, and the main source of GGT in normal human serum is from the liver. A common adverse reaction to chemotherapeutic drugs is liver function injury, which can be followed by elevated GGT. Chemotherapeutic drugs may also damage the kidneys, myocardium and other organs and tissues, and GGT elevation occurs. It is worth noting that elevated GGT can occur after the onset of certain neoplastic diseases, such as primary hepatocellular carcinoma. Tumor cells in patients with primary hepatocellular carcinoma are actively proliferating and can overproduce GGT, resulting in elevated serum GGT levels. The cause of elevated GGT in patients may be related to chemotherapeutic drugs, and patients are advised to follow up regularly under the treatment of specialists and adjust the treatment if necessary.