The 10-year survival rate of mixed connective tissue disease is about 80% as long as the patient actively cooperates with the doctor’s treatment, which varies according to the patient’s own situation, the severity of the disease and other factors. Generally, the main treatment is medication to control the disease, relieve symptoms and prevent complications. Mixed connective tissue disease usually has a long course and the treatment cycle is usually 2 to 5 years. It is mainly treated with hormones (such as prednisone acetate tablets, etc.), immunosuppressants (such as methotrexate, cyclophosphamide, etc.), and antimalarials (such as hydroxychloroquine, etc.) as prescribed by the doctor. Generally, after treatment, the prognosis is better and the survival time is longer, the 10-year survival rate is about 80%, which varies according to the patient’s own situation, the severity of the disease and other factors. Patients should pay attention to maintain good dietary habits, daily routine and mentality, quit smoking and alcohol, which will help the recovery of the disease. At the same time, patients with stabilized conditions should have regular follow-ups, and they can go to the hospital once every three to six months to observe the changes in their conditions. It is recommended that patients with mixed connective tissue disease should consult the Rheumatology and Immunology Department in a timely manner, under the guidance of the doctor for standardized treatment and regular follow-up.