There is no such thing as which medication works well with Adapalene Gel to treat acne pimples, there are individual differences and no generalizations can be made. Generally, Adapalene Gel can be used in conjunction with Benzoyl Peroxide, Benzoyl Peroxide, Azelaic Acid, and other medications to treat acne, pimples, and other acne treatments. 1. Fusidic acid cream: Fusidic acid cream is a dermatological antibiotic, suitable for staphylococcus, streptococcus, propionibacterium acnes and other bacteria caused by skin infections, the main indications include: pustules, boils, sweating inflammation, folliculitis, acne vulgaris and other dermatological disorders, the use of the drug should be prohibited for patients who are allergic to any one of the ingredients in the fusidic acid cream. 2. Benzoyl peroxide gel: Benzoyl peroxide gel is a keratolytic agent that can be used in the treatment of acne vulgaris, patients may experience burning sensation, itching, redness, swelling and other symptoms, and this drug should be prohibited for patients with acne breakouts. 3. Azelaic acid ointment: azelaic acid ointment is a dermatological drug that can be used for the local treatment of mild and moderate inflammatory acne, patients who are allergic to azelaic acid should be prohibited from using this drug. In addition to the use of medication, patients should pay attention to personal hygiene, keep the affected area clean and dry skin, avoid squeezing, digging acne, so as not to cause infection. It is recommended that patients strictly follow the doctor’s instructions, do not change the dose of drugs or private abuse of drugs.