When a patient wakes up with a swollen mouth, generally speaking, the common causes are mainly the following. i. The patient eats seafood, mangoes, tomatoes and other allergy-prone foods at night, although there is no obvious allergic performance at that time. During nighttime sleep the organism has a delayed allergic reaction, which can be manifested as a significant swelling of the lips. At this time, the patient can be treated with anti-allergic drugs such as oral loratadine and paracetamol. If the patient’s swollen lips still cannot be relieved, it is recommended to go to the dermatology department of the hospital as soon as possible to give anti-allergy or desensitization treatment, so as to relieve the symptoms of swollen lips. Second, mosquito bites during the patient’s sleep at night can also cause significant swelling of the mouth. In this case, as the patient has a strong compensatory ability, the local inflammation and swelling can be reduced by taking drugs such as oral swelling and pain, amoxicillin, etc. Avoid eating spicy and stimulating food to avoid progressive aggravation of lip swelling symptoms.