Urine occult blood with 1 plus sign and 25 red blood cells is not a serious condition and may often be caused by a combination of infection or a combination of stones. It is recommended that the patient go to the hospital for further tests to clarify. Ultrasound of the urinary system, CT of the urinary system, and urine culture tests are needed to further clarify the cause, as well as platelet or coagulation tests to find out if there is a systemic bleeding disorder. If there are urinary stones or urinary tract infections, the above mentioned changes in urinary occult blood may occur. This is a common urological condition and not a serious urological disease. It can be cured by anti-infection treatment or extracorporeal shock wave lithotripsy without any residual effects. When thrombocytopenia or coagulation disorders are present, urinary tract bleeding can occur. It may be accompanied by bleeding from the skin and mucous membranes or bleeding from the gums, which can be improved by platelet transfusion or oral medication to stop bleeding or platelet boosting. It needs to be evaluated in hematology and is not a serious urological condition.