Objective: To retrospectively analyze the surgical experience, surgical risks, complications and management of resection of difficult sites of hepatic occupancy. Methods: Forty-seven patients were divided into the first hilar group, second hilar group and caudate lobe group according to the adjacent location of the tumor, and all patients underwent partial hepatectomy. Results The mean operative time (289.6.4-62.2) min, mean bleeding volume (602.3.4±256.4) ml, mean intraoperative blood transfusion (524.0±325.9) ml. The incidence of surgical complications in the three groups was 61.5%, 26.9% and 25%, respectively. Serious surgical complications were bile leak (27.7%), bleeding (6.4%) and postoperative liver failure (2.1%).Three perioperative deaths were caused by bleeding in two cases and liver failure in l case. Conclusion: The freeing of the liver and the exposure of important blood vessels and bile ducts are very critical in surgery for liver occupancy in difficult sites, and the delicate treatment of the tiny intrahepatic ducts during resection of the tumor can significantly reduce postoperative complications. Comprehensive preoperative evaluation is very important to judge the feasibility and predict the risk of surgery. Once the important vessels adjacent to the tumor are injured, it not only leads to bleeding, but also often leads to necrosis of the corresponding liver lobe because of the obstruction of outflow tract or flow channel, and the injury of the second hepatic hilar vessel is more lethal than the injury of the first hepatic hilar.