The main symptoms of advanced acute leukemia are:
1. Bleeding: The degree of bleeding acute leukemia symptoms varies. Bleeding from the skin, mucous membranes and nasal cavity is common. Skin and mucosal bleeding is characterized by a variable number of purplish-red petechiae or petechiae that do not recede when pressed. If there is no new bleeding, these petechiae and petechiae gradually fade within about a week, but patients often show symptoms of acute leukemia in which the old bleeding spots just disappear and new ones appear again. Some patients may also develop conjunctival and fundus vascular hemorrhage, which can affect vision. In severe cases, the patient’s internal organs can also bleed, and intracranial hemorrhage is a symptom of severe acute leukemia. The main cause of bleeding in patients is a significant decrease in platelets, but it is also associated with various factors such as a decrease in coagulation factors, hyperfibrinolysis, and infiltration of leukemic cells into the blood vessels.
2. Fever: Acute leukemia symptoms make the vast majority of patients have fever, manifesting as low- or high-grade fever, mostly of the recurrent irregular fever type. Most patients with leukemia have a high number of leukocytes in the peripheral blood, but most of these cells do not have the anti-infective effect of normal leukocytes. The large proliferation of leukemic cells causes a decrease in normal granulocytes, making the patient susceptible to infections with pathogenic factors such as bacteria and viruses, causing hyperthermia. Infections of the upper respiratory tract, oral cavity, urinary tract, anus and skin infections are the most common symptoms of acute leukemia.
3. Anemia: It is often the first acute leukemia symptom and progressively worsens. The main symptoms of acute leukemia are pale skin and mucous membranes, dizziness, weakness, palpitations, shortness of breath and excessive sweating. The reason for the anemia is because the excessive proliferation of abnormal white blood cells inhibits the production of normal red blood cells, and the life span of the generated red blood cells is shorter than normal red blood cells, i.e., the quantity and quality of red blood cells are reduced, so the patient often shows the more severe the disease, the more severe the acute leukemia symptoms of anemia.