Smoker’s disease causes two clinical manifestations: 1. Ischemic manifestations: dizziness, epilepsy, mental decline, etc.; 2. Hemorrhagic manifestations: sudden intracranial hemorrhage, causing the corresponding clinical manifestations: headache, epilepsy, coma, recurrent bleeding, mental decline, limb paralysis, etc. Current treatment: If the collateral circulation can be compensated, it can be spontaneously cured. For those who cannot compensate, with progressive worsening of symptoms, surgical treatment can be considered: direct or indirect revascularization. Internal treatment is mainly symptomatic. For ischemic onset, vasodilators and anticoagulants can be applied. For hemorrhagic onset, vascular hemostatic agents and antifibrinolytic drugs can be applied. Since the cause of the disease is not clear and the disease is chronic in origin, it is important to have a low-fat and low-salt diet, control blood pressure, blood lipids, blood sugar, appropriate physical activity, and pay attention to review.