Squeezing a hole in one breast can be seen in cystic hyperplasia of the breast, intraductal papilloma of the breast, breast cancer and other diseases. 1. Breast cystic hyperplasia: It is a disease caused by the imbalance of estrogen and progesterone, in which the breast tissue has hyperplasia and other lesions. The main symptoms include cyclic breast pain and nipple discharge, which is usually plasma. The main treatment is symptomatic and can be treated with drugs such as tamoxifen. 2. Intraductal papilloma of the breast: It is commonly found in menstruating women and is more common near the nipple. The main symptom is nipple discharge, mostly bloody. The main treatment method is surgery. 3. Breast cancer: the main symptoms are painless lumps, nipple discharge and cellulite. The main treatments are surgery and radiotherapy. At the same time, mastitis and dilated milk ducts can also be seen in the case of breast overflow, which need to be carefully identified. Squeezing one side of the breast a hole overflow should be timely medical care, under the guidance of the doctor to clarify the diagnosis, standardized acceptance of treatment.