The measurement of serum 5-hydroxytryptamine levels can help in the diagnosis and treatment of premature ejaculation 2012-09-28 Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Department of Urology, Wang Yanbin Editor: International Medical Press Keywords: Urology A recent study published in the Chinese Journal of Clinical Physicians (electronic version) points out that the measurement of serum 5-hydroxytryptamine levels in patients with premature ejaculation may provide a method to diagnose and guide the treatment of premature ejaculation. In a recent study published in the Chinese Journal of Clinical Practice, it was suggested that measuring serum 5-hydroxytryptamine levels in patients with premature ejaculation might provide a method for diagnosing and guiding its treatment. Researchers from the Center for Reproductive Medicine, Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University collected serum from 71 patients with primary premature ejaculation before and after sertraline hydrochloride and 64 normal men, and measured their 5-hydroxytryptamine levels using an enzyme-linked immunoassay. The results showed that (1) the serum 5-hydroxytryptamine level [61.9 ng/ml (median)] was significantly lower in the test group than in the control group (120.6 ng/ml); (2) the serum 5-hydroxytryptamine level [98.9 ng/ml (median)] was significantly higher in the test group than in the pre-drug level; (3) the area under the ROC curve for the diagnosis of premature ejaculation by 5-hydroxytryptamine was 0.974, with a significant difference; the cut-point value of 5-hydroxytryptamine for the diagnosis of premature ejaculation was 86.4 ng/ml, with a sensitivity of 92.2% and a specificity of 93.0%.