Cefaclor normal dosage, generally does not produce significant damage to the kidneys, but overdose leads to cefaclor cumulative toxicity, which can lead to kidney injury. Cefaclor belongs to the third generation of broad-spectrum cephalosporin antibiotics, mainly metabolized by the kidneys, under normal circumstances, will not cause significant damage to the kidneys, when the drug is used in excess or the user himself has renal insufficiency, it may lead to nephrotoxicity, damage to the kidneys. People with renal insufficiency should reduce the use of renal metabolism drugs, the use of Cefaclor also need to be reduced, and during the use of water, need to drink more water, to promote renal metabolism, reduce nephrotoxicity. During the use of Cefaclor, a light diet is needed, and should not be combined with penicillin, which is prone to cross allergic reactions.