During the quadruple period generally refers to the quadruple drug treatment period, quadruple drug treatment during the stool shaped stop and dilute may be intestinal flora disorders, acute gastroenteritis, gastrointestinal dysfunction and other disease factors caused by the need for targeted treatment under the guidance of the doctor, such as general treatment, drug treatment and so on. 1. Intestinal flora disorders: probiotics can be used, such as Bifidobacterium bifidum, Bacillus licheniformis, etc. Loperamide can be used to stop diarrhea when accompanied by severe diarrhea. 2. Acute gastroenteritis: ciprofloxacin can be used for anti-infection treatment when accompanied by bacterial infection, and montelukast can be used for stopping diarrhea in case of severe diarrhea. 3. Gastrointestinal dysfunction: maintain a good state of mind and emotions, adjust diet, avoid eating raw, cold, spicy and other foods that are irritating to the gastrointestinal mucosa, accompanied by obvious mental symptoms can be treated with antidepressant drugs such as amitriptyline. If the stool becomes dilute again after stopping the medication during the quadruple drug treatment, it is recommended to go to the hospital and ask the doctor to make a judgment and then give a treatment plan.