Whether or not a negative cryptococcal antigen test is a complete recovery needs to be judged in conjunction with other indicators. The complete disappearance of physical symptoms and lesions is considered recovery; the presence of physical symptoms and some lesions is not considered a complete cure. A negative test for cryptococcal antigen, disappearance of clinical symptoms, and no lesions detected by imaging are signs of good treatment and recovery. Further examination reveals that there are still related foci, such as mycobacterial balls in the lungs, thickening of the meninges in the brain and edema of the brain tissue, and is accompanied by related pulmonary and neurological symptoms, which is a sign of non-recovery. Once cryptococcal infection is detected and accompanied by obvious clinical symptoms, it is necessary to be admitted to the hospital in a timely manner and receive standardized treatment under the guidance of the clinician to avoid delaying the condition.