If chest pain occurs after one course of treatment for multiple myeloma, chemotherapy can be given to control the progression of multiple myeloma, as well as the use of non-steroidal painkillers to relieve pain, and the reduction of activity to prevent fracture. 1. Chest pain in multiple myeloma is generally not a common clinical manifestation of myeloma, and pain after one course of treatment indicates bone destruction, which may be related to the progression of the disease. At this time, it is necessary to treat the etiology of the disease, and relieve the pain by administering chemotherapy to control the development of myeloma. Drugs include bortezomib, cyclophosphamide, lenalidomide and so on. 2. If the pain is severe within a short period of time, non-steroidal analgesics such as ibuprofen extended-release capsules, acetaminophen, flurbiprofen, indomethacin, etc. can be given to provide analgesic treatment. If you want to relieve chest pain completely, you still need to control multiple myeloma through chemotherapy to achieve the goal. 3. Advanced osteolytic destruction can lead to pain in lumbar vertebrae and sternum, accompanied by fracture, and the activity level should be reduced to prevent fracture. If diagnosed with multiple myeloma, it is recommended to carry out standardized treatment as early as possible, and the drugs need to be applied under the guidance of doctors, not self-medication.