There are two main causes of vocal fold hypertrophy: inflammation and tumor. Its main manifestation is hoarseness. Vocal fold hypertrophy caused by inflammation may sometimes be combined with inflammation of the throat, leading to local discomfort in the throat. In contrast, patients caused by tumors may have some more serious manifestations, such as dyspnea, and the symptoms gradually worsen, accompanied by coughing, coughing up sputum and hemoptysis. Vocal cord hypertrophy caused by inflammation may also cause reflux problems, resulting in adverse digestive tract reactions such as heartburn, acid reflux and gastric distention.