Diabetic foot is one of the serious complications of diabetes, and once it occurs, it not only increases the financial burden of the patient, but also affects the quality of life. In particular, the treatment time of diabetic foot is long, easy to recur, and the condition is so serious that it has to be treated by surgical amputation in life-threatening cases, which makes patients fearful. In recent years, the incidence of diabetic foot in China has been on the rise, approaching and exceeding that of European and American countries. The treatment of diabetic foot has also become the focus of treatment and research for endocrinologists. How to detect the danger signals of diabetic foot early, achieve early prevention, avoid serious complications, as well as the rehabilitation treatment to return to normal life as soon as possible after having diabetic foot is the concern of all diabetic patients. Yu Haiyan, Department of Internal Medicine, Wuxi Mental Health Center What is a diabetic foot? Who is prone to diabetic foot? Diabetic foot is a foot with diabetic macrovascular and microangiopathy, accompanied by diabetic peripheral neuropathy, resulting in insufficient blood supply to the lower extremities and causing ulcers due to infection etc. under the action of external forces. Most patients show reduced sensation to cold, heat and pain in both lower limbs or feet, and encounter minor burns or abrasions that can easily cause local ulcers that do not heal easily. Poorly controlled infection can develop deeper and cause necrosis of the toes or limbs. Elderly diabetic patients with long disease duration, poor blood sugar control, peripheral neuropathy and poor vision are prone to diabetic foot. So, what tests do diabetics need to do to detect diabetic foot early? The first thing to look for is peripheral neuropathy in diabetes. Early detection of abnormal sensations in the lower extremities, without obvious reasons have toes and calves numbness pins and needles, pain, burning, insect crawling sensation, knife pain, vague pain and calf cramps, feet soft tread cotton feeling and other abnormal sensations, all suggest that you may be complicating the diabetic nerve damage, especially the patients with hypoesthesia, lack of perception of pain, to do neurological examination. The next step is to detect diabetic vasculopathy early. Vascular lesions initially feel cold feet at night when sleeping, hot water bags do not work, quilts cover overnight does not work; and then when walking calf fatigue, can only walk and stop, or have calf cramps, pale and cold feet, low skin temperature, cold toes and limp walking and other symptoms, if these conditions occur to think about whether the vascular problems, as soon as possible to the diabetes specialist for screening of changes in the blood vessel wall. The focus should be on the cause and basis of the rotten foot, to find out whether it is mainly caused by insufficient blood supply or neuropathy, whether there is any co-infection, what kind of bacterial infection, how deep the rupture is, and whether the bone is involved. Therefore, the following tests should be done: 1. metabolic control: blood glucose, glycated hemoglobin, lipids, blood pressure, etc.; 2. vascular lesions: ankle-brachial artery pressure ratio (ABI), vascular ultrasound, or magnetic resonance angiography (MRA), or CT angiography (CTA), or even digital subtraction angiography (DSA), etc.; 3. neuropathy: vibration threshold, electromyography; 4. x-ray of the affected foot; 5. 6.Vital organ function: ECG, cardiac ultrasound, etc., liver and kidney function, brain CT, lung function, etc. Although diabetic foot can be prevented, but there are still many diabetic patients wait until their feet have ulcerated before they find out, and seek medical attention everywhere, the treatment time is long, but the improvement is very slow, diabetic foot need how to treat? The treatment of diabetic foot is a long and comprehensive treatment process with the cooperation of multidisciplinary doctors such as endocrinology, vascular surgery, orthopedics, radiology and rehabilitation. According to the patient’s specific situation, surgical treatment such as anti-infection, vascular stent, bypass and even amputation are given in the acute stage, and after the condition is stabilized, anticoagulation, vascular dilation and nerve nutrition are given. Therefore, the prevention of diabetic foot is still very important, diabetic patients should pay attention to the correct way to wash their feet in daily life, cut their nails, wear suitable soft shoes, visit the diabetic specialist regularly, get timely guidance, and work with diabetic doctors and nurses to avoid the occurrence of diabetic foot, so that the quality of life can be improved.