Clinical work has revealed that in recent years, the quality of human spermatozoa has been declining with environmental and estrogenic toxin pollution and other factors. There are many factors that lead to oligospermia, inflammation, drug effects; alcoholism, excessive smoking, drugs can inhibit sperm production; prostatitis, varicocele, etc. can inhibit sperm production. The normal sperm function of men depends on the normal function of the hypothalamus-pituitary-gonadal axis, any of which will affect the sperm function, and other diseases such as thyroid and adrenal gland will also affect the function of the gonad and cause spermatozoa. 2.Cryptorchidism Some studies report that about 30% to 60% of patients with unilateral cryptorchidism are infertile, while 50% to 100% of patients with bilateral cryptorchidism are infertile, and about 9% of patients with oligospermia have cryptorchidism. In addition to the degeneration of cryptorchidism that affects sperm production, the other side of the testicle with complete descent may also have different degrees of damage, which may be due to the influence of anti-sperm antibodies produced by cryptorchidism on normal testicles. 3.Inflammation of the genitourinary system Including orchitis, epididymitis, seminal vesiculitis, prostatitis, urethritis, etc. The proportion of such patients in oligospermia is the largest. The inflammation of the genitourinary tract can directly affect the spermatogenic function of the testes, and can also cause the production of anti-sperm antibodies in the blood or semen, affecting the pH of the semen, plus the direct killing effect of pathogens on sperm, which can cause a reduction in sperm. 4, varicose spermatozoa Varicose spermatozoa cause infertility accounts for 30% to 40% of male infertility. Due to the elevated testicular temperature and toxin accumulation, the spermatogenic function of the testes is affected, causing oligospermia and, in severe cases, azoospermia. The symptoms of varicocele are not obvious at first, but in severe cases, the scrotum may feel swollen and the vascular masses like earthworm are protruding above. Semen examination shows that the sperm count decreases, the mobility is poor, and the number of deformed sperm increases. The temperature of the scrotum is too high. The varicose ducts in the testes, which are specifically used to produce sperm, are very sensitive to temperature changes, and the appropriate temperature in this area is 2 to 3°C lower than the body temperature. Therefore, male friends should wear less tight pants, less sauna baths, avoid electromagnetic radiation and high temperatures, and develop good habits.