Bleeding from squeezing anal glands is mainly related to the damage of local mucous membrane, and is also considered to be related to hemorrhoids, anal fissure, anal fistula, rectal cancer and so on. 1. Damaged local mucous membrane: when squeezing the anal glands with excessive force, the local mucous membrane is damaged and the capillaries are ruptured, which is accompanied by bleeding, pain and other symptoms. 2. Hemorrhoids: the etiology has not been fully clarified, but it is considered to be related to factors such as anal cushion displacement and varicose veins. Typical symptoms of patients are perianal prolapse, anal itching, blood in stool, anal pain, etc. When localized lesions, it can be manifested as bleeding phenomenon of squeezing anal glands. 3. Anal fissure: the cause of the disease is not completely clear, and may be associated with excessive force during defecation, infection, anal canal stenosis, and so on. Typical symptoms of patients are constipation, anal itching, etc., can also be due to fecal matter extrusion and anal gland bleeding phenomenon. 4. Anal fistula: the disease is related to the history of perianal abscess, bad life habits, etc. The main symptoms of patients are anal itching, perianal pus, perianal pain, etc., which can also be manifested as bleeding phenomenon of squeezing anal glands. 5. Rectal cancer: the cause of the disease is not clear, but it may be related to environmental factors and genetic factors. Usually, patients do not have obvious symptoms in early stage, and some of them may have symptoms such as blood in stool, frequency of bowel movement, feeling of dropping in anus, etc., which may also be manifested as bleeding from squeezing anal glands. It is recommended that the person who squeezes the anal glands bleeding to consult a doctor for examination in time, so as to clarify the disease and follow the doctor’s instructions for treatment, and recently pay attention to strengthen the perianal care, avoiding stimulation of foreign body friction.