The clinical significance of gallbladder enlargement, the most common gallbladder abnormality, i.e. whether it is combined with chromosomal abnormalities or other abnormalities of the biliary tract, has been controversial among scholars in the past. Some studies have considered gallbladder enlargement as a high-risk indicator of combined aneuploidy or biliary tract abnormalities. It has been suggested that after prenatal detection of fetal gallbladder enlargement, careful search should be made for combined anomalies and other indicators of aneuploidy, and if so, pregnant women should be advised to undergo fetal chromosomal examination. Nevertheless, in later studies, scholars concluded that gallbladder enlargement did not seem to increase the risk of combined aneuploidy or biliary anomalies. It has been suggested that gallbladder enlargement is not a predictor of fetal aneuploidy.