Immunological infertility is infertility caused by autoimmunity or alloimmunity to reproductive system antigens and accounts for about 10% of all infertility cases. The clinical etiology is divided into alloimmunity, local immunity and autoimmunity: 1. Alloimmunity: male sperm and semen as antigens produce antibodies in the female body, called anti-sperm antibodies. Anti-sperm antibodies cause sperm to lose vitality and thus cannot combine with the egg and cause infertility; 2. Local immunity: local tissues inside the uterus are immune to sperm and will absorb sperm entering the reproductive tract to produce anti-sperm antibodies leading to infertility, such as the endometrium; 3. Autoimmunity: anti-sperm antibodies produced by the woman herself, which can affect the penetration of sperm into the egg and thus prevent fertilization from being completed, leading to infertility. This antibody can affect the penetration of sperm into the egg, thus preventing fertilization from being completed and leading to infertility. Immune infertility can be solved by certain medical means, such as immunosuppressive treatment with adrenocorticotropic hormones, artificial insemination by removing surface antibodies after semen collection, and the application of testosterone to reduce the number of anti-sperm antibodies before waiting for an opportunity to conceive. Patients can ask their doctors for advice to find a solution that suits them.