Symptoms of advanced pulmonary heart disease are cyanosis, restlessness, edema, palpitations, and lethargy, as well as decreased blood pressure and pallor. Cor pulmonale is a heart disease caused by pulmonary hypertension. Usually, symptoms such as cyanosis, restlessness, apathy, shortness of breath, worsening of dyspnea, and lethargy will appear before death in the late stage of cor pulmonale. Severe cases will be complicated with pulmonary encephalopathy, followed by edema, palpitations, arrhythmia and other symptoms of right heart failure. At the same time, patients with advanced pulmonary heart disease will also appear to systemic microcirculatory perfusion decreased dramatically, cell damage-based shock symptoms, mostly manifested as a drop in blood pressure, pale, cold extremities, coma, etc., indicating that the patient’s body multi-organ failure. Pulmonary heart disease is a chronic disease, generally early and timely treatment, can effectively delay the development of the disease. All in all, when checked out with pulmonary heart disease, patients need to go to the hospital in a timely manner, cooperate with the doctor for standardized treatment, regular follow-up.