The onset of Parkinson’s disease is slow, the early symptoms are not very obvious, and there are individual differences, generally divided into the following four conditions: 1. Resting tremor. Tremor is often the earliest manifestation of the disease, usually with unilateral finger rubbing-like movements, and later progresses to involuntary rhythmic tremors in the ipsilateral lower extremity and contralateral extremity at rest, which may decrease or stop when changing position or movement. Tremors may increase with changes in mood. 2. Muscle rigidity. In the early stage, it mostly starts with unilateral limbs, and patients feel stiffness of joints and tightness of muscles. When the facial muscles are affected, a “mask face” with a dull expression may appear; when the trunk, limbs and knees are flexed, a “triple bend posture” may occur. 3. Delay in movement. In the early stage, the fine movements of the upper limbs become slower, such as tying shoelaces, buttoning and other movements are much slower than before, and even cannot be completed successfully. Writing also gradually becomes difficult, the handwriting is bent, and the smaller the handwriting is, it is called “small writing syndrome”. When walking, it is difficult to start, and once you start walking, your body leans forward and your pace becomes smaller and faster, and you cannot stop in time, which is called “panic gait”. During walking, the coordinated swing of the affected upper limb decreases or even disappears; it is difficult to turn around, so that it is possible to use several consecutive small broken steps. 4. Combination of other symptoms. Sometimes patients may have a combination of reduced speech and low monotone voice, swallowing difficulties, salivation, sleep disorders, depression or dementia. The results of many years of clinical observation show that the changes in the condition of Parkinson’s disease patients with different treatment behaviors are very significant: 1, the majority of patients who began to receive reasonable treatment at the early onset of the disease can delay the development of the disease, the disease is relatively stable, life can basically take care of themselves. 2. Patients who are treated but interrupted from time to time are mostly unable to control their disease well, and their condition will be repeated and aggravated to varying degrees. 3.Patients who develop to an advanced stage before starting treatment, the disease is often already very serious, and the available treatments are limited to improve the disease, and patients usually have obvious disabilities. 4. In patients with rapidly developing disease, a large proportion of them live alone, are withdrawn and live a closed life. In contrast, a higher percentage of patients with family care, cheerful personality and social interaction have stable disease control, indicating that family care is crucial.