The severity of shingles is not related to the location, but rather to comorbidities, age, immunity, and whether or not it is treated in a timely manner, so shingles on the thighs is not serious in most cases. Herpes zoster is a skin disease caused by the activation of the varicella zoster virus in the body, and is most common on the chest and back, head, face, buttocks and other parts of the body, but also on the thighs, where there are clusters of erythematous spots and blisters along the nerves, accompanied by pain and itching. Treatment is mainly based on antiviral therapy, while pain relief, anti-inflammatory, and prevention of complications are needed. Herpes zoster has a certain degree of self-limitation, if it grows on the thighs, after systematic and standardized treatment, it is generally not serious and will not leave sequelae. If the shingles patients are older, or have comorbidities (such as diabetes, etc.), or untimely treatment of shingles patients, may be left with severe postherpetic neuralgia. If patients with shingles who are immunocompromised, such as patients with AIDS, patients with malignant tumors, patients with long-term use of immunosuppressants, etc., systemic symptoms, such as fever, generalized erythema, blisters, etc., and viral meningitis, etc., can occur in severe cases. It is recommended that patients with herpes zoster on the thighs go to the hospital in time to get a clear diagnosis and then follow the doctor’s instructions to take appropriate treatment measures.