If the blisters are small, they will fade on their own without being picked. Small blisters will usually gradually absorb on their own and then crust over and peel off, but larger blisters will not heal on their own. There are many reasons for blisters to form, usually due to dermatologic conditions. If the blister is large, it is usually necessary to pick it up and apply a wet compress. Some of the larger blisters will not subside in time even after they have been picked, and still need to be treated with glucocorticoids under the guidance of a doctor to subside completely. Before picking a blister, you need to wash your hands with hand sanitizer or soap to prevent the bacteria on your hands from infecting the location of the blister when you pick it, then use medical alcohol to wipe the area of the blister, and be careful not to break the blister during the wiping process. Therefore, in the discovery of small blisters, in general, try not to take the initiative to break, in addition, it should be noted that if the blisters are caused by burns or burns, remember not to break at will.