The causes of chest tightness and shortness of breath at work include heart failure, bronchial asthma, unstable angina, chronic obstructive pulmonary disease, etc. The treatment includes medication and surgery. 1. Heart failure: If heart failure is considered to be the cause of chest tightness and shortness of breath, then you can give drugs such as cardiac glycosides and furosemide diuretic treatment. 2. Bronchial asthma: for patients with bronchial asthma, drugs such as terbutaline can be given to diastolic bronchial therapy. 3. Unstable angina: If it is unstable angina, then isosorbide nitrate and other drugs can be given to expand the coronary treatment, and if necessary, can be given to interventional surgery. 4. Chronic Obstructive Pulmonary Disease (COPD): For chest tightness and shortness of breath caused by COPD, it is necessary to give oxygen, hormones, cephalosporin and other antibacterial treatment. Finally, the phenomenon of chest tightness and shortness of breath at work, please go to the hospital in time for examination, the above drugs need to follow the doctor’s instructions.