Insulin resistance is mainly a condition in which insulin levels are normal, or very high, and blood glucose is not well controlled. For most people with type 2 diabetes, the first major problem to reduce insulin resistance is weight loss. Weight control, mainly exercise and diet control, is also a fundamental and effective method. Patients who have difficulty losing weight can intervene with medications such as metformin and insulin sensitizers such as pioglitazone and rosiglitazone. For particularly obese patients, liposuction or gastric diversion surgery can be helpful in improving weight as well as improving insulin sensitivity. During the treatment of diabetes, some pro-secretory agents are able to control blood glucose, but they do not control insulin resistance, and it appears that after blood glucose control, the diet becomes bigger and bigger instead, and obesity becomes more serious, leading to the occurrence of a vicious circle. If you must choose, you can consider glimepiride, etc., which has a certain insulin sensitizing effect. The most fundamental way to improve insulin resistance is to control diet and reduce weight.