Hepatitis B patients generally need interferon best when there is an immune response. In addition, low surface antigen can also be considered for interferon. 1. Immune response: in the five tests of hepatitis B, the standard of immune response is that the liver function has abnormal symptoms, and the liver function still can’t be restored to normal after receiving liver-protecting and enzyme-lowering treatments or can be restored only for a short period of time, which can be regarded as immune response, and it is recommended to receive interferon treatment. 2. Low surface antigen: if the surface antigen of hepatitis B is less than 3000ng/mL, without cirrhosis, interferon treatment can also be considered to promote the surface antigen to become negative. Interferon is used for antiviral, inhibiting cell proliferation and regulating immunity, common adverse effects include fever, headache, myalgia and fatigue, etc. It is prohibited for those who are allergic to interferon, and should be used with caution for those who are allergic to antibiotics. In addition, the application of interferon has certain risks, patients need to use under the guidance of a specialist.